Contribution of allelic imbalance to colorectal cancer

In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to c...

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Autores principales:	Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d1e862be9834942b8b1513c12b2e466
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spelling	oai:doaj.org-article:0d1e862be9834942b8b1513c12b2e4662021-12-02T14:39:05ZContribution of allelic imbalance to colorectal cancer10.1038/s41467-018-06132-12041-1723https://doaj.org/article/0d1e862be9834942b8b1513c12b2e4662018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06132-1https://doaj.org/toc/2041-1723In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.Kimmo PalinEsa PitkänenMikko TurunenBiswajyoti SahuPäivi PihlajamaaTeemu KiviojaEevi KaasinenNiko VälimäkiUlrika A. HänninenTatiana CajusoMervi AavikkoSari TuupanenOuti KilpivaaraLinda van den BergJohanna KondelinTomas TanskanenRiku KatainenMarta GrauHeli RauanheimoRoosa-Maria PlakettiAurora TairaPäivi SuloTuomo HartonenKashyap DaveBernhard SchmiererSandeep BotlaMaria SokolovaAnna VähärautioKornelia GladyszHalit OngenEmmanouil DermitzakisJesper Bertram BramsenTorben Falck ØrntoftClaus Lindbjerg AndersenAri RistimäkiAnna LepistöLaura Renkonen-SinisaloJukka-Pekka MecklinJussi TaipaleLauri A. AaltonenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kimmo Palin Esa Pitkänen Mikko Turunen Biswajyoti Sahu Päivi Pihlajamaa Teemu Kivioja Eevi Kaasinen Niko Välimäki Ulrika A. Hänninen Tatiana Cajuso Mervi Aavikko Sari Tuupanen Outi Kilpivaara Linda van den Berg Johanna Kondelin Tomas Tanskanen Riku Katainen Marta Grau Heli Rauanheimo Roosa-Maria Plaketti Aurora Taira Päivi Sulo Tuomo Hartonen Kashyap Dave Bernhard Schmierer Sandeep Botla Maria Sokolova Anna Vähärautio Kornelia Gladysz Halit Ongen Emmanouil Dermitzakis Jesper Bertram Bramsen Torben Falck Ørntoft Claus Lindbjerg Andersen Ari Ristimäki Anna Lepistö Laura Renkonen-Sinisalo Jukka-Pekka Mecklin Jussi Taipale Lauri A. Aaltonen Contribution of allelic imbalance to colorectal cancer
description	In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.
format	article
author	Kimmo Palin Esa Pitkänen Mikko Turunen Biswajyoti Sahu Päivi Pihlajamaa Teemu Kivioja Eevi Kaasinen Niko Välimäki Ulrika A. Hänninen Tatiana Cajuso Mervi Aavikko Sari Tuupanen Outi Kilpivaara Linda van den Berg Johanna Kondelin Tomas Tanskanen Riku Katainen Marta Grau Heli Rauanheimo Roosa-Maria Plaketti Aurora Taira Päivi Sulo Tuomo Hartonen Kashyap Dave Bernhard Schmierer Sandeep Botla Maria Sokolova Anna Vähärautio Kornelia Gladysz Halit Ongen Emmanouil Dermitzakis Jesper Bertram Bramsen Torben Falck Ørntoft Claus Lindbjerg Andersen Ari Ristimäki Anna Lepistö Laura Renkonen-Sinisalo Jukka-Pekka Mecklin Jussi Taipale Lauri A. Aaltonen
author_facet	Kimmo Palin Esa Pitkänen Mikko Turunen Biswajyoti Sahu Päivi Pihlajamaa Teemu Kivioja Eevi Kaasinen Niko Välimäki Ulrika A. Hänninen Tatiana Cajuso Mervi Aavikko Sari Tuupanen Outi Kilpivaara Linda van den Berg Johanna Kondelin Tomas Tanskanen Riku Katainen Marta Grau Heli Rauanheimo Roosa-Maria Plaketti Aurora Taira Päivi Sulo Tuomo Hartonen Kashyap Dave Bernhard Schmierer Sandeep Botla Maria Sokolova Anna Vähärautio Kornelia Gladysz Halit Ongen Emmanouil Dermitzakis Jesper Bertram Bramsen Torben Falck Ørntoft Claus Lindbjerg Andersen Ari Ristimäki Anna Lepistö Laura Renkonen-Sinisalo Jukka-Pekka Mecklin Jussi Taipale Lauri A. Aaltonen
author_sort	Kimmo Palin
title	Contribution of allelic imbalance to colorectal cancer
title_short	Contribution of allelic imbalance to colorectal cancer
title_full	Contribution of allelic imbalance to colorectal cancer
title_fullStr	Contribution of allelic imbalance to colorectal cancer
title_full_unstemmed	Contribution of allelic imbalance to colorectal cancer
title_sort	contribution of allelic imbalance to colorectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0d1e862be9834942b8b1513c12b2e466
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Contribution of allelic imbalance to colorectal cancer

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