Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation

The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.

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Bibliographic Details
Main Authors: Jana Sánchez-Wandelmer, Franziska Kriegenburg, Sabrina Rohringer, Martina Schuschnig, Rubén Gómez-Sánchez, Bettina Zens, Susana Abreu, Ralph Hardenberg, David Hollenstein, Jieqiong Gao, Christian Ungermann, Sascha Martens, Claudine Kraft, Fulvio Reggiori
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba
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Internet

https://doaj.org/article/0d25d8e1163b4f90ae02c9c439b13fba

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