RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

RAC1 is a downstream target of the Wnt signaling that promotes intestinal stem cell expansion and tumorigenesis. Here, the authors identify the specific splice variant RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor trea...

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Autores principales:	Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V. Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E. Hall, Mark Agostino, John Cassidy, Colin Nixon, Alex von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen J. Sansom, Kevin B. Myant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d5fa07d90ab4bcca894bd613a859024
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spelling	oai:doaj.org-article:0d5fa07d90ab4bcca894bd613a8590242021-12-02T16:45:10ZRAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways10.1038/s41467-021-22531-32041-1723https://doaj.org/article/0d5fa07d90ab4bcca894bd613a8590242021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22531-3https://doaj.org/toc/2041-1723RAC1 is a downstream target of the Wnt signaling that promotes intestinal stem cell expansion and tumorigenesis. Here, the authors identify the specific splice variant RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment.Victoria GudiñoSebastian Öther-Gee PohlCaroline V. BillardPatrizia CammareriAlfonso BoladoStuart AitkenDavid StevensonAdam E. HallMark AgostinoJohn CassidyColin NixonAlex von KriegsheimPaz FreileLinda PopplewellGeorge DicksonLaura MurphyAnn WheelerMalcolm DunlopFarhat DinDouglas StrathdeeOwen J. SansomKevin B. MyantNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victoria Gudiño Sebastian Öther-Gee Pohl Caroline V. Billard Patrizia Cammareri Alfonso Bolado Stuart Aitken David Stevenson Adam E. Hall Mark Agostino John Cassidy Colin Nixon Alex von Kriegsheim Paz Freile Linda Popplewell George Dickson Laura Murphy Ann Wheeler Malcolm Dunlop Farhat Din Douglas Strathdee Owen J. Sansom Kevin B. Myant RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
description	RAC1 is a downstream target of the Wnt signaling that promotes intestinal stem cell expansion and tumorigenesis. Here, the authors identify the specific splice variant RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment.
format	article
author	Victoria Gudiño Sebastian Öther-Gee Pohl Caroline V. Billard Patrizia Cammareri Alfonso Bolado Stuart Aitken David Stevenson Adam E. Hall Mark Agostino John Cassidy Colin Nixon Alex von Kriegsheim Paz Freile Linda Popplewell George Dickson Laura Murphy Ann Wheeler Malcolm Dunlop Farhat Din Douglas Strathdee Owen J. Sansom Kevin B. Myant
author_facet	Victoria Gudiño Sebastian Öther-Gee Pohl Caroline V. Billard Patrizia Cammareri Alfonso Bolado Stuart Aitken David Stevenson Adam E. Hall Mark Agostino John Cassidy Colin Nixon Alex von Kriegsheim Paz Freile Linda Popplewell George Dickson Laura Murphy Ann Wheeler Malcolm Dunlop Farhat Din Douglas Strathdee Owen J. Sansom Kevin B. Myant
author_sort	Victoria Gudiño
title	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
title_short	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
title_full	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
title_fullStr	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
title_full_unstemmed	RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
title_sort	rac1b modulates intestinal tumourigenesis via modulation of wnt and egfr signalling pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0d5fa07d90ab4bcca894bd613a859024
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RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

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