In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide thera...

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Autores principales: N. N. Parayath, S. B. Stephan, A. L. Koehne, P. S. Nelson, M. T. Stephan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0d662657f13f42b8babe9affe4eb6b2f
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