In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide thera...

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Autores principales:	N. N. Parayath, S. B. Stephan, A. L. Koehne, P. S. Nelson, M. T. Stephan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0d662657f13f42b8babe9affe4eb6b2f
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spelling	oai:doaj.org-article:0d662657f13f42b8babe9affe4eb6b2f2021-12-02T17:31:09ZIn vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo10.1038/s41467-020-19486-22041-1723https://doaj.org/article/0d662657f13f42b8babe9affe4eb6b2f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19486-2https://doaj.org/toc/2041-1723Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide therapeutic effects in mouse models of cancer or viral infection.N. N. ParayathS. B. StephanA. L. KoehneP. S. NelsonM. T. StephanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. N. Parayath S. B. Stephan A. L. Koehne P. S. Nelson M. T. Stephan In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
description	Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide therapeutic effects in mouse models of cancer or viral infection.
format	article
author	N. N. Parayath S. B. Stephan A. L. Koehne P. S. Nelson M. T. Stephan
author_facet	N. N. Parayath S. B. Stephan A. L. Koehne P. S. Nelson M. T. Stephan
author_sort	N. N. Parayath
title	In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
title_short	In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
title_full	In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
title_fullStr	In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
title_full_unstemmed	In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
title_sort	in vitro-transcribed antigen receptor mrna nanocarriers for transient expression in circulating t cells in vivo
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0d662657f13f42b8babe9affe4eb6b2f
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In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

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