A severe leakage of intermediates to shunt products in acarbose biosynthesis

A severe leakage of intermediates to shunt products in acarbose biosynthesis

Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarb...

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Autores principales: Qinqin Zhao, Yuchang Luo, Xin Zhang, Qianjin Kang, Dan Zhang, Lili Zhang, Linquan Bai, Zixin Deng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0db4c8b5727345a0bbbd13552ff25ed1
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spelling oai:doaj.org-article:0db4c8b5727345a0bbbd13552ff25ed12021-12-02T15:39:28ZA severe leakage of intermediates to shunt products in acarbose biosynthesis10.1038/s41467-020-15234-82041-1723https://doaj.org/article/0db4c8b5727345a0bbbd13552ff25ed12020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15234-8https://doaj.org/toc/2041-1723Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarbose titer in Actinoplanes species.Qinqin ZhaoYuchang LuoXin ZhangQianjin KangDan ZhangLili ZhangLinquan BaiZixin DengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qinqin Zhao
Yuchang Luo
Xin Zhang
Qianjin Kang
Dan Zhang
Lili Zhang
Linquan Bai
Zixin Deng
A severe leakage of intermediates to shunt products in acarbose biosynthesis
description Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarbose titer in Actinoplanes species.
format article
author Qinqin Zhao
Yuchang Luo
Xin Zhang
Qianjin Kang
Dan Zhang
Lili Zhang
Linquan Bai
Zixin Deng
author_facet Qinqin Zhao
Yuchang Luo
Xin Zhang
Qianjin Kang
Dan Zhang
Lili Zhang
Linquan Bai
Zixin Deng
author_sort Qinqin Zhao
title A severe leakage of intermediates to shunt products in acarbose biosynthesis
title_short A severe leakage of intermediates to shunt products in acarbose biosynthesis
title_full A severe leakage of intermediates to shunt products in acarbose biosynthesis
title_fullStr A severe leakage of intermediates to shunt products in acarbose biosynthesis
title_full_unstemmed A severe leakage of intermediates to shunt products in acarbose biosynthesis
title_sort severe leakage of intermediates to shunt products in acarbose biosynthesis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0db4c8b5727345a0bbbd13552ff25ed1
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