A severe leakage of intermediates to shunt products in acarbose biosynthesis

A severe leakage of intermediates to shunt products in acarbose biosynthesis

Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the flux to these shunt products can increase acarb...

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Autores principales: Qinqin Zhao, Yuchang Luo, Xin Zhang, Qianjin Kang, Dan Zhang, Lili Zhang, Linquan Bai, Zixin Deng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/0db4c8b5727345a0bbbd13552ff25ed1
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