Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

Fibroadipogenic precursor cells (FAPs) contribute to fibrosis and adipogenic replacement in muscular dystrophies. Here, the authors show that FAPs contribute to adipogenic loss in mouse models of limb girdle muscular dystrophy 2B via a mechanism dependent on expression of Annexin A2, and that this p...

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Autores principales:	Marshall W. Hogarth, Aurelia Defour, Christopher Lazarski, Eduard Gallardo, Jordi Diaz Manera, Terence A. Partridge, Kanneboyina Nagaraju, Jyoti K. Jaiswal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0de39a40d2af49bb9bb31819d111a9f9
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spelling	oai:doaj.org-article:0de39a40d2af49bb9bb31819d111a9f92021-12-02T16:57:44ZFibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B10.1038/s41467-019-10438-z2041-1723https://doaj.org/article/0de39a40d2af49bb9bb31819d111a9f92019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10438-zhttps://doaj.org/toc/2041-1723Fibroadipogenic precursor cells (FAPs) contribute to fibrosis and adipogenic replacement in muscular dystrophies. Here, the authors show that FAPs contribute to adipogenic loss in mouse models of limb girdle muscular dystrophy 2B via a mechanism dependent on expression of Annexin A2, and that this process can be prevented by its pharmacologic inhibition in mice.Marshall W. HogarthAurelia DefourChristopher LazarskiEduard GallardoJordi Diaz ManeraTerence A. PartridgeKanneboyina NagarajuJyoti K. JaiswalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marshall W. Hogarth Aurelia Defour Christopher Lazarski Eduard Gallardo Jordi Diaz Manera Terence A. Partridge Kanneboyina Nagaraju Jyoti K. Jaiswal Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
description	Fibroadipogenic precursor cells (FAPs) contribute to fibrosis and adipogenic replacement in muscular dystrophies. Here, the authors show that FAPs contribute to adipogenic loss in mouse models of limb girdle muscular dystrophy 2B via a mechanism dependent on expression of Annexin A2, and that this process can be prevented by its pharmacologic inhibition in mice.
format	article
author	Marshall W. Hogarth Aurelia Defour Christopher Lazarski Eduard Gallardo Jordi Diaz Manera Terence A. Partridge Kanneboyina Nagaraju Jyoti K. Jaiswal
author_facet	Marshall W. Hogarth Aurelia Defour Christopher Lazarski Eduard Gallardo Jordi Diaz Manera Terence A. Partridge Kanneboyina Nagaraju Jyoti K. Jaiswal
author_sort	Marshall W. Hogarth
title	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
title_short	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
title_full	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
title_fullStr	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
title_full_unstemmed	Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
title_sort	fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2b
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0de39a40d2af49bb9bb31819d111a9f9
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Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

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