Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer

The 78 kilodalton glucose-regulated protein (GRP78) is a major endoplasmic reticulum (ER) molecular chaperone with antiapoptotic properties and a key regulator of the unfolded protein response (UPR). ER-stress induction of GRP78 in cancer cells represents a major pro-survival branch of the UPR. Panc...

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Autores principales: Dat P. Ha, Yuan-Li Tsai, Amy S. Lee
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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BiP
Acceso en línea:https://doaj.org/article/0df6786ddc6d40c6932382b12c33996e
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