Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Abstract Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Palb2, and Brca2, individually and in combination, along with one copy of Trp53, in the mammary gland of nulliparous female mice. We observed a...

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Bibliographic Details
Main Authors: Yanying Huo, Pier Selenica, Amar H. Mahdi, Fresia Pareja, Kelly Kyker-Snowman, Ying Chen, Rahul Kumar, Arnaud Da Cruz Paula, Thais Basili, David N. Brown, Xin Pei, Nadeem Riaz, Yongmei Tan, Yu-Xiu Huang, Tao Li, Nicola J. Barnard, Jorge S. Reis-Filho, Britta Weigelt, Bing Xia
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/0e18ff09a2e84f079cd0677a6df9cca3
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