Sensing Host Arginine Is Essential for <italic toggle="yes">Leishmania</italic> Parasites’ Intracellular Development

Sensing Host Arginine Is Essential for <italic toggle="yes">Leishmania</italic> Parasites’ Intracellular Development

ABSTRACT Arginine homeostasis in lysosomes is critical for the growth and metabolism of mammalian cells. Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis. During infection, parasites encounter arginine deprivation, which is m...

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Autores principales: Adele Goldman-Pinkovich, Sriram Kannan, Roni Nitzan-Koren, Madhu Puri, Harsh Pawar, Yael Bar-Avraham, Jacquelyn McDonald, Aakash Sur, Wen-Wei Zhang, Greg Matlashewski, Rentala Madhubala, Shulamit Michaeli, Peter J. Myler, Dan Zilberstein
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
host-pathogen interaction
Leishmania
amino acid sensing
amino acid transport
intracellular parasitism
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/0e194efdd6f54cbbaf5c38700237ad61
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https://doaj.org/article/0e194efdd6f54cbbaf5c38700237ad61

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