Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.
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Nature Portfolio
2017
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oai:doaj.org-article:0e2259c2b1d0444fa38da6636f4173302021-12-02T14:42:55ZIntegrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder10.1038/s41467-017-00831-x2041-1723https://doaj.org/article/0e2259c2b1d0444fa38da6636f4173302017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00831-xhttps://doaj.org/toc/2041-1723Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.Hyun Ji NohRuqi TangJason FlannickColm O’DushlaineRoss SwoffordDaniel HowriganDiane P. GenereuxJeremy JohnsonGerard van GrootheestEdna GrünblattErik AnderssonDiana R. DjurfeldtParesh D. PatelMichele KoltookianChristina M. HultmanMichele T. PatoCarlos N. PatoSteven A. RasmussenMichael A. JenikeGregory L. HannaS. Evelyn StewartJames A. KnowlesStephan RuhrmannHans-Jörgen GrabeMichael WagnerChristian RückCarol A. MathewsSusanne WalitzaDaniëlle C. CathGuoping FengElinor K. KarlssonKerstin Lindblad-TohNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hyun Ji Noh Ruqi Tang Jason Flannick Colm O’Dushlaine Ross Swofford Daniel Howrigan Diane P. Genereux Jeremy Johnson Gerard van Grootheest Edna Grünblatt Erik Andersson Diana R. Djurfeldt Paresh D. Patel Michele Koltookian Christina M. Hultman Michele T. Pato Carlos N. Pato Steven A. Rasmussen Michael A. Jenike Gregory L. Hanna S. Evelyn Stewart James A. Knowles Stephan Ruhrmann Hans-Jörgen Grabe Michael Wagner Christian Rück Carol A. Mathews Susanne Walitza Daniëlle C. Cath Guoping Feng Elinor K. Karlsson Kerstin Lindblad-Toh Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| description |
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD. |
| format |
article |
| author |
Hyun Ji Noh Ruqi Tang Jason Flannick Colm O’Dushlaine Ross Swofford Daniel Howrigan Diane P. Genereux Jeremy Johnson Gerard van Grootheest Edna Grünblatt Erik Andersson Diana R. Djurfeldt Paresh D. Patel Michele Koltookian Christina M. Hultman Michele T. Pato Carlos N. Pato Steven A. Rasmussen Michael A. Jenike Gregory L. Hanna S. Evelyn Stewart James A. Knowles Stephan Ruhrmann Hans-Jörgen Grabe Michael Wagner Christian Rück Carol A. Mathews Susanne Walitza Daniëlle C. Cath Guoping Feng Elinor K. Karlsson Kerstin Lindblad-Toh |
| author_facet |
Hyun Ji Noh Ruqi Tang Jason Flannick Colm O’Dushlaine Ross Swofford Daniel Howrigan Diane P. Genereux Jeremy Johnson Gerard van Grootheest Edna Grünblatt Erik Andersson Diana R. Djurfeldt Paresh D. Patel Michele Koltookian Christina M. Hultman Michele T. Pato Carlos N. Pato Steven A. Rasmussen Michael A. Jenike Gregory L. Hanna S. Evelyn Stewart James A. Knowles Stephan Ruhrmann Hans-Jörgen Grabe Michael Wagner Christian Rück Carol A. Mathews Susanne Walitza Daniëlle C. Cath Guoping Feng Elinor K. Karlsson Kerstin Lindblad-Toh |
| author_sort |
Hyun Ji Noh |
| title |
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| title_short |
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| title_full |
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| title_fullStr |
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| title_full_unstemmed |
Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| title_sort |
integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0e2259c2b1d0444fa38da6636f417330 |
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