A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers

Abstract PT150, a novel competitive glucocorticoid receptor (GR) antagonist, has proven safe in animal models, healthy volunteers, and people with depression. Our study is the first to investigate PT150’s safety with alcohol use. The primary objective of this study was to evaluate pharmacodynamic in...

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Autores principales: Claire Morice, Dewleen G. Baker, Marguerite M. Patel, Tracy L. Nolen, Kayla Nowak, Shawn Hirsch, Thomas R. Kosten, Christopher D. Verrico
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0e47702aff834151b977af287dc2a85f
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