A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.

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Auteurs principaux: Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Science
Q
Accès en ligne:https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e
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https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e

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