A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.

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Autores principales:	Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e
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spelling	oai:doaj.org-article:0e5d0907f6a14928a23a27cda5802f8e2021-12-02T14:39:15ZA neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis10.1038/ncomms121052041-1723https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12105https://doaj.org/toc/2041-1723RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.Yanzhe GaoElizabeth Mutter-RottmayerAlicia M. GreenwaltDennis GoldfarbFeng YanYang YangRaquel C. Martinez-ChacinKenneth H. PearceSatoshi TateishiMichael B. MajorCyrus VaziriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanzhe Gao Elizabeth Mutter-Rottmayer Alicia M. Greenwalt Dennis Goldfarb Feng Yan Yang Yang Raquel C. Martinez-Chacin Kenneth H. Pearce Satoshi Tateishi Michael B. Major Cyrus Vaziri A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
description	RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.
format	article
author	Yanzhe Gao Elizabeth Mutter-Rottmayer Alicia M. Greenwalt Dennis Goldfarb Feng Yan Yang Yang Raquel C. Martinez-Chacin Kenneth H. Pearce Satoshi Tateishi Michael B. Major Cyrus Vaziri
author_facet	Yanzhe Gao Elizabeth Mutter-Rottmayer Alicia M. Greenwalt Dennis Goldfarb Feng Yan Yang Yang Raquel C. Martinez-Chacin Kenneth H. Pearce Satoshi Tateishi Michael B. Major Cyrus Vaziri
author_sort	Yanzhe Gao
title	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
title_short	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
title_full	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
title_fullStr	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
title_full_unstemmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis
title_sort	neomorphic cancer cell-specific role of mage-a4 in trans-lesion synthesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e
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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

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