Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

Exosomes function as intercellular information transmitters and are candidates for delivery of therapeutic agents. Here the authors present EXOtic, a synthetic biology device for in-situ production of designer exosomes and demonstrate in vivo application in models of Parkinson's disease.

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Autores principales:	Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi, Ghislaine Charpin-El Hamri, Marie Daoud El-Baba, Pratik Saxena, Simon Ausländer, Kelly R. Tan, Martin Fussenegger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e6a2ce92e194d368bbcb60650f4592b
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spelling	oai:doaj.org-article:0e6a2ce92e194d368bbcb60650f4592b2021-12-02T16:56:38ZDesigner exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment10.1038/s41467-018-03733-82041-1723https://doaj.org/article/0e6a2ce92e194d368bbcb60650f4592b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03733-8https://doaj.org/toc/2041-1723Exosomes function as intercellular information transmitters and are candidates for delivery of therapeutic agents. Here the authors present EXOtic, a synthetic biology device for in-situ production of designer exosomes and demonstrate in vivo application in models of Parkinson's disease.Ryosuke KojimaDaniel BojarGiorgio RizziGhislaine Charpin-El HamriMarie Daoud El-BabaPratik SaxenaSimon AusländerKelly R. TanMartin FusseneggerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryosuke Kojima Daniel Bojar Giorgio Rizzi Ghislaine Charpin-El Hamri Marie Daoud El-Baba Pratik Saxena Simon Ausländer Kelly R. Tan Martin Fussenegger Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
description	Exosomes function as intercellular information transmitters and are candidates for delivery of therapeutic agents. Here the authors present EXOtic, a synthetic biology device for in-situ production of designer exosomes and demonstrate in vivo application in models of Parkinson's disease.
format	article
author	Ryosuke Kojima Daniel Bojar Giorgio Rizzi Ghislaine Charpin-El Hamri Marie Daoud El-Baba Pratik Saxena Simon Ausländer Kelly R. Tan Martin Fussenegger
author_facet	Ryosuke Kojima Daniel Bojar Giorgio Rizzi Ghislaine Charpin-El Hamri Marie Daoud El-Baba Pratik Saxena Simon Ausländer Kelly R. Tan Martin Fussenegger
author_sort	Ryosuke Kojima
title	Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
title_short	Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
title_full	Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
title_fullStr	Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
title_full_unstemmed	Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
title_sort	designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for parkinson’s disease treatment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e6a2ce92e194d368bbcb60650f4592b
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Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

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