BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.

Breast tumor kinase (BRK), also known as protein tyrosine kinase 6 (PTK6), is a non-receptor tyrosine kinase overexpressed in more that 60% of human breast carcinomas. The overexpression of BRK has been shown to sensitize mammary epithelial cells to mitogenic signaling and to promote cell proliferat...

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Autores principales: Sayem Miah, Raghuveera Kumar Goel, Chenlu Dai, Natasha Kalra, Erika Beaton-Brown, Edward T Bagu, Keith Bonham, Kiven E Lukong
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/0eb0e42ee72c498a98472e66fd3b4c9a
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