Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling.

The small GTPase RhoA is a central signaling enzyme that is involved in various cellular processes such as cytoskeletal dynamics, transcription, and cell cycle progression. Many signal transduction pathways activate RhoA-for instance, Gαq-coupled Histamine 1 Receptor signaling via Gαq-dependent acti...

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Autores principales: Jason Z Zhang, Andy H Nguyen, Shigeki Miyamoto, Joan Heller Brown, Andrew D McCulloch, Jin Zhang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2020
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Acceso en línea:https://doaj.org/article/0ebb54bacf2e4652ac3dc47d3752c53f
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