Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

Hair follicles (HFs) are sensitive to chemotherapy but recover from quiescent HF stem cells, although sometimes chemotherapy results in permanent loss. Here, Kim et al. establish a model of permanent chemotherapy-induced alopecia to uncover the underlying mechanisms depleting human HF stem cells.

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Autores principales:	Jin Yong Kim, Jungyoon Ohn, Ji-Seon Yoon, Bo Mi Kang, Minji Park, Sookyung Kim, Woochan Lee, Sungjoo Hwang, Jong-Il Kim, Kyu Han Kim, Ohsang Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ebcac53511c43cd9ca4c49f28dcf1a2
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spelling	oai:doaj.org-article:0ebcac53511c43cd9ca4c49f28dcf1a22021-12-02T17:02:15ZPriming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy10.1038/s41467-019-11665-02041-1723https://doaj.org/article/0ebcac53511c43cd9ca4c49f28dcf1a22019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11665-0https://doaj.org/toc/2041-1723Hair follicles (HFs) are sensitive to chemotherapy but recover from quiescent HF stem cells, although sometimes chemotherapy results in permanent loss. Here, Kim et al. establish a model of permanent chemotherapy-induced alopecia to uncover the underlying mechanisms depleting human HF stem cells.Jin Yong KimJungyoon OhnJi-Seon YoonBo Mi KangMinji ParkSookyung KimWoochan LeeSungjoo HwangJong-Il KimKyu Han KimOhsang KwonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin Yong Kim Jungyoon Ohn Ji-Seon Yoon Bo Mi Kang Minji Park Sookyung Kim Woochan Lee Sungjoo Hwang Jong-Il Kim Kyu Han Kim Ohsang Kwon Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
description	Hair follicles (HFs) are sensitive to chemotherapy but recover from quiescent HF stem cells, although sometimes chemotherapy results in permanent loss. Here, Kim et al. establish a model of permanent chemotherapy-induced alopecia to uncover the underlying mechanisms depleting human HF stem cells.
format	article
author	Jin Yong Kim Jungyoon Ohn Ji-Seon Yoon Bo Mi Kang Minji Park Sookyung Kim Woochan Lee Sungjoo Hwang Jong-Il Kim Kyu Han Kim Ohsang Kwon
author_facet	Jin Yong Kim Jungyoon Ohn Ji-Seon Yoon Bo Mi Kang Minji Park Sookyung Kim Woochan Lee Sungjoo Hwang Jong-Il Kim Kyu Han Kim Ohsang Kwon
author_sort	Jin Yong Kim
title	Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
title_short	Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
title_full	Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
title_fullStr	Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
title_full_unstemmed	Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
title_sort	priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ebcac53511c43cd9ca4c49f28dcf1a2
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Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

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