Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).
<h4>Background</h4>Pathogenic aneuploidies involve the concept of dosage-sensitive genes leading to over- and underexpression phenotypes. Monosomy 21 in human leads to mental retardation and skeletal, immune and respiratory function disturbances. Most of the human condition corresponds t...
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Autores principales: | Glòria Arqué, Vassiliki Fotaki, David Fernández, María Martínez de Lagrán, Maria L Arbonés, Mara Dierssen |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2008
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Materias: | |
Acceso en línea: | https://doaj.org/article/0ebf15927bdb41ad85aa87c511de0217 |
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