Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.

Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide poly...

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Autores principales: Rahatul Islam, Mashiur Rahaman, Hammadul Hoque, Nazmul Hasan, Shamsul H Prodhan, Asfia Ruhama, Nurnabi Azad Jewel
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/0ed139ea57cc46c6abe020abab650279
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