Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.

Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide poly...

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Autores principales:	Rahatul Islam, Mashiur Rahaman, Hammadul Hoque, Nazmul Hasan, Shamsul H Prodhan, Asfia Ruhama, Nurnabi Azad Jewel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ed139ea57cc46c6abe020abab650279
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spelling	oai:doaj.org-article:0ed139ea57cc46c6abe020abab6502792021-12-02T20:04:17ZComputational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.1932-620310.1371/journal.pone.0259691https://doaj.org/article/0ed139ea57cc46c6abe020abab6502792021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259691https://doaj.org/toc/1932-6203Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide polymorphisms (nsSNPs) are responsible for various types of cancer progression, e.g. melanoma, lung cancer, and breast cancer. Hence, this study is designed to identify the malignant missense mutation of CDK4 from the single nucleotide polymorphism database (dbSNP) by incorporating computational algorithms. Out of 239 nsSNPs; G15S, D140Y and D140H were predicted to be highly malignant variants which may have a devastating impact on protein structure or function. We also found defective binding motif of these three mutants with the CDK4 inhibitor ribociclib and ATP. However, by incorporating molecular dynamic simulation, our study concludes that the superiority of G15S than the other two mutants (D140Y and D140H) in destabilizing proteins nature.Rahatul IslamMashiur RahamanHammadul HoqueNazmul HasanShamsul H ProdhanAsfia RuhamaNurnabi Azad JewelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259691 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rahatul Islam Mashiur Rahaman Hammadul Hoque Nazmul Hasan Shamsul H Prodhan Asfia Ruhama Nurnabi Azad Jewel Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
description	Cycline-dependent kinase 4 (CDK4), an enzyme of the cycline dependent or Ser/Thr protein kinase family, plays a role in cell cycle progression (G1 phase) by phosphorylating a tumor suppressor protein called pRB. Alteration of this enzyme due to missense mutation/ nonsynonymous single nucleotide polymorphisms (nsSNPs) are responsible for various types of cancer progression, e.g. melanoma, lung cancer, and breast cancer. Hence, this study is designed to identify the malignant missense mutation of CDK4 from the single nucleotide polymorphism database (dbSNP) by incorporating computational algorithms. Out of 239 nsSNPs; G15S, D140Y and D140H were predicted to be highly malignant variants which may have a devastating impact on protein structure or function. We also found defective binding motif of these three mutants with the CDK4 inhibitor ribociclib and ATP. However, by incorporating molecular dynamic simulation, our study concludes that the superiority of G15S than the other two mutants (D140Y and D140H) in destabilizing proteins nature.
format	article
author	Rahatul Islam Mashiur Rahaman Hammadul Hoque Nazmul Hasan Shamsul H Prodhan Asfia Ruhama Nurnabi Azad Jewel
author_facet	Rahatul Islam Mashiur Rahaman Hammadul Hoque Nazmul Hasan Shamsul H Prodhan Asfia Ruhama Nurnabi Azad Jewel
author_sort	Rahatul Islam
title	Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
title_short	Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
title_full	Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
title_fullStr	Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
title_full_unstemmed	Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.
title_sort	computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with cdk4 gene.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0ed139ea57cc46c6abe020abab650279
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Computational and structural based approach to identify malignant nonsynonymous single nucleotide polymorphisms associated with CDK4 gene.

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