Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6

Abstract Although we have shown that avian reovirus (ARV) p17-mediated inhibition of Akt leads to induction of autophagy, the precise mechanisms remain largely unknown. This study has identified a specific mechanism by which ARV coordinately regulates the degradation of ribosomal proteins by p17-med...

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Bibliographic Details
Main Authors: Wei-Ru Huang, Pei-I Chi, Hung-Chuan Chiu, Jue-Liang Hsu, Brent L. Nielsen, Tsai-Ling Liao, Hung-Jen Liu
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/0f15e8c5b9164b95ac8d3b6b24d492eb
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