Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that un...
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Nature Portfolio
2019
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oai:doaj.org-article:0f2708368b2a4696b47220ee30732ce82021-12-02T17:32:23ZGenomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma10.1038/s41467-019-08578-32041-1723https://doaj.org/article/0f2708368b2a4696b47220ee30732ce82019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08578-3https://doaj.org/toc/2041-1723Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes.Cristina LópezKortine KleinheinzSietse M. AukemaMarius RohdeStephan H. BernhartDaniel HübschmannRabea WagenerUmut H. ToprakFrancesco RaimondiMarkus KreuzSebastian M. WaszakZhiqin HuangLina SieverlingNagarajan ParamasivamJulian SeufertStephanie SungaleeRobert B. RussellJulia BausingerHelene KretzmerOle AmmerpohlAnke K. BergmannHans BinderArndt BorkhardtBenedikt BrorsAlexander ClaviezGero DooseLars FeuerbachAndrea HaakeMartin-Leo HansmannJessica HoellMichael HummelJan O. KorbelChris LawerenzDido LenzeBernhard RadlwimmerJulia RichterPhilip RosenstielAndreas RosenwaldMarkus B. SchilhabelHarald SteinStephan StilgenbauerPeter F. StadlerMonika SzczepanowskiMarc A. WenigerMarc ZapatkaRoland EilsPeter LichterMarkus LoefflerPeter MöllerLorenz TrümperWolfram KlapperICGC MMML-Seq ConsortiumSteve HoffmannRalf KüppersBirgit BurkhardtMatthias SchlesnerReiner SiebertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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DOAJ |
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EN |
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Science Q |
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Science Q Cristina López Kortine Kleinheinz Sietse M. Aukema Marius Rohde Stephan H. Bernhart Daniel Hübschmann Rabea Wagener Umut H. Toprak Francesco Raimondi Markus Kreuz Sebastian M. Waszak Zhiqin Huang Lina Sieverling Nagarajan Paramasivam Julian Seufert Stephanie Sungalee Robert B. Russell Julia Bausinger Helene Kretzmer Ole Ammerpohl Anke K. Bergmann Hans Binder Arndt Borkhardt Benedikt Brors Alexander Claviez Gero Doose Lars Feuerbach Andrea Haake Martin-Leo Hansmann Jessica Hoell Michael Hummel Jan O. Korbel Chris Lawerenz Dido Lenze Bernhard Radlwimmer Julia Richter Philip Rosenstiel Andreas Rosenwald Markus B. Schilhabel Harald Stein Stephan Stilgenbauer Peter F. Stadler Monika Szczepanowski Marc A. Weniger Marc Zapatka Roland Eils Peter Lichter Markus Loeffler Peter Möller Lorenz Trümper Wolfram Klapper ICGC MMML-Seq Consortium Steve Hoffmann Ralf Küppers Birgit Burkhardt Matthias Schlesner Reiner Siebert Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| description |
Burkitt lymphoma (BL) is the most common pediatric B-cell lymphoma. Here, within the International Cancer Genome Consortium, the authors performed whole genome and transcriptome sequencing of 39 sporadic BL, describing the landscape of mutations, structural variants, and mutational processes that underpin this disease how alterations on different cellular levels cooperate in deregulating key pathways and complexes. |
| format |
article |
| author |
Cristina López Kortine Kleinheinz Sietse M. Aukema Marius Rohde Stephan H. Bernhart Daniel Hübschmann Rabea Wagener Umut H. Toprak Francesco Raimondi Markus Kreuz Sebastian M. Waszak Zhiqin Huang Lina Sieverling Nagarajan Paramasivam Julian Seufert Stephanie Sungalee Robert B. Russell Julia Bausinger Helene Kretzmer Ole Ammerpohl Anke K. Bergmann Hans Binder Arndt Borkhardt Benedikt Brors Alexander Claviez Gero Doose Lars Feuerbach Andrea Haake Martin-Leo Hansmann Jessica Hoell Michael Hummel Jan O. Korbel Chris Lawerenz Dido Lenze Bernhard Radlwimmer Julia Richter Philip Rosenstiel Andreas Rosenwald Markus B. Schilhabel Harald Stein Stephan Stilgenbauer Peter F. Stadler Monika Szczepanowski Marc A. Weniger Marc Zapatka Roland Eils Peter Lichter Markus Loeffler Peter Möller Lorenz Trümper Wolfram Klapper ICGC MMML-Seq Consortium Steve Hoffmann Ralf Küppers Birgit Burkhardt Matthias Schlesner Reiner Siebert |
| author_facet |
Cristina López Kortine Kleinheinz Sietse M. Aukema Marius Rohde Stephan H. Bernhart Daniel Hübschmann Rabea Wagener Umut H. Toprak Francesco Raimondi Markus Kreuz Sebastian M. Waszak Zhiqin Huang Lina Sieverling Nagarajan Paramasivam Julian Seufert Stephanie Sungalee Robert B. Russell Julia Bausinger Helene Kretzmer Ole Ammerpohl Anke K. Bergmann Hans Binder Arndt Borkhardt Benedikt Brors Alexander Claviez Gero Doose Lars Feuerbach Andrea Haake Martin-Leo Hansmann Jessica Hoell Michael Hummel Jan O. Korbel Chris Lawerenz Dido Lenze Bernhard Radlwimmer Julia Richter Philip Rosenstiel Andreas Rosenwald Markus B. Schilhabel Harald Stein Stephan Stilgenbauer Peter F. Stadler Monika Szczepanowski Marc A. Weniger Marc Zapatka Roland Eils Peter Lichter Markus Loeffler Peter Möller Lorenz Trümper Wolfram Klapper ICGC MMML-Seq Consortium Steve Hoffmann Ralf Küppers Birgit Burkhardt Matthias Schlesner Reiner Siebert |
| author_sort |
Cristina López |
| title |
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_short |
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_full |
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_fullStr |
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_full_unstemmed |
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma |
| title_sort |
genomic and transcriptomic changes complement each other in the pathogenesis of sporadic burkitt lymphoma |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/0f2708368b2a4696b47220ee30732ce8 |
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