Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

Abstract The role of the influenza virus polymerase complex in host range restriction has been well-studied and several host range determinants, such as the polymerase PB2-E627K and PB2-D701N mutations, have been identified. However, there may be additional, currently unknown, human adaptation polym...

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Main Authors: Yasuha Arai, Norihito Kawashita, Kozue Hotta, Phuong Vu Mai Hoang, Hang Le Khanh Nguyen, Thach Co Nguyen, Cuong Duc Vuong, Thanh Thi Le, Mai Thi Quynh Le, Kosuke Soda, Madiha S. Ibrahim, Tomo Daidoji, Tatsuya Takagi, Tatsuo Shioda, Takaaki Nakaya, Toshihiro Ito, Futoshi Hasebe, Yohei Watanabe
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/0f3cc61631004b7ab2180d3aa419df7d
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https://doaj.org/article/0f3cc61631004b7ab2180d3aa419df7d

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