Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemokine and cytokine driven inflammatory defenses.

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Autores principales: Alí Alejo, M. Begoña Ruiz-Argüello, Sergio M. Pontejo, María del Mar Fernández de Marco, Margarida Saraiva, Bruno Hernáez, Antonio Alcamí
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b948
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