Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemokine and cytokine driven inflammatory defenses.

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Autores principales:	Alí Alejo, M. Begoña Ruiz-Argüello, Sergio M. Pontejo, María del Mar Fernández de Marco, Margarida Saraiva, Bruno Hernáez, Antonio Alcamí
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b948
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spelling	oai:doaj.org-article:0f471da0fe0f47cfb7468c4516c8b9482021-12-02T17:33:06ZChemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation10.1038/s41467-018-04098-82041-1723https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b9482018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04098-8https://doaj.org/toc/2041-1723Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemokine and cytokine driven inflammatory defenses.Alí AlejoM. Begoña Ruiz-ArgüelloSergio M. PontejoMaría del Mar Fernández de MarcoMargarida SaraivaBruno HernáezAntonio AlcamíNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alí Alejo M. Begoña Ruiz-Argüello Sergio M. Pontejo María del Mar Fernández de Marco Margarida Saraiva Bruno Hernáez Antonio Alcamí Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
description	Cytokines play critical roles in the anti-viral response but their contribution in vivo remains unclear. Here the authors show that viral CrmD is a major virulence determinant and requires the SECRET and TNF binding domains to counter both the chemokine and cytokine driven inflammatory defenses.
format	article
author	Alí Alejo M. Begoña Ruiz-Argüello Sergio M. Pontejo María del Mar Fernández de Marco Margarida Saraiva Bruno Hernáez Antonio Alcamí
author_facet	Alí Alejo M. Begoña Ruiz-Argüello Sergio M. Pontejo María del Mar Fernández de Marco Margarida Saraiva Bruno Hernáez Antonio Alcamí
author_sort	Alí Alejo
title	Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
title_short	Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
title_full	Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
title_fullStr	Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
title_full_unstemmed	Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
title_sort	chemokines cooperate with tnf to provide protective anti-viral immunity and to enhance inflammation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f471da0fe0f47cfb7468c4516c8b948
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Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

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