PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.

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Auteurs principaux: Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
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Internet

https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d

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