PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.

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Autores principales:	Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
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spelling	oai:doaj.org-article:0f6811ec82d941be9a6362cf200f312d2021-12-02T14:42:15ZPrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts10.1038/s41467-020-19570-72041-1723https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19570-7https://doaj.org/toc/2041-1723Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.Ann Liza PibergerAkhil BowryRichard D. W. KellyAlexandra K. WalkerDaniel González-AcostaLaura J. BaileyAidan J. DohertyJuan MéndezJoanna R. MorrisHelen E. BryantEva PetermannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ann Liza Piberger Akhil Bowry Richard D. W. Kelly Alexandra K. Walker Daniel González-Acosta Laura J. Bailey Aidan J. Doherty Juan Méndez Joanna R. Morris Helen E. Bryant Eva Petermann PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
description	Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
format	article
author	Ann Liza Piberger Akhil Bowry Richard D. W. Kelly Alexandra K. Walker Daniel González-Acosta Laura J. Bailey Aidan J. Doherty Juan Méndez Joanna R. Morris Helen E. Bryant Eva Petermann
author_facet	Ann Liza Piberger Akhil Bowry Richard D. W. Kelly Alexandra K. Walker Daniel González-Acosta Laura J. Bailey Aidan J. Doherty Juan Méndez Joanna R. Morris Helen E. Bryant Eva Petermann
author_sort	Ann Liza Piberger
title	PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
title_short	PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
title_full	PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
title_fullStr	PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
title_full_unstemmed	PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
title_sort	primpol-dependent single-stranded gap formation mediates homologous recombination at bulky dna adducts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
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PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

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