The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90

The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90

Xestoquinone is a polycyclic quinone-type metabolite with a reported antitumor effect. We tested the cytotoxic activity of xestoquinone on a series of hematological cancer cell lines. The antileukemic effect of xestoquinone was evaluated in vitro and in vivo. This marine metabolite suppressed the pr...

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Autores principales: Kuan-Chih Wang, Mei-Chin Lu, Kai-Cheng Hsu, Mohamed El-Shazly, Shou-Ping Shih, Ssu-Ting Lien, Fu-Wen Kuo, Shyh-Chyun Yang, Chun-Lin Chen, Yu-Chen S. H. Yang
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
polycyclic quinone
xestoquinone
apoptosis
anticancer
topoisomerase
reactive oxygen species (ROS)
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/0f779598f48a428d996bf6389ff62567
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https://doaj.org/article/0f779598f48a428d996bf6389ff62567

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