Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.

Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by cortical and spinal motor neuron dysfunction. Routine magnetic resonance imaging (MRI) studies have previously shown hypointense signal in the motor cortex on T(2)-weighted images in some ALS patients, h...

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Main Authors: Justin Y Kwan, Suh Young Jeong, Peter Van Gelderen, Han-Xiang Deng, Martha M Quezado, Laura E Danielian, John A Butman, Lingye Chen, Elham Bayat, James Russell, Teepu Siddique, Jeff H Duyn, Tracey A Rouault, Mary Kay Floeter
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/0f7888cfdc984453a07d2db754a8f3a8
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https://doaj.org/article/0f7888cfdc984453a07d2db754a8f3a8

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