MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation

Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.

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Autores principales: Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A. Esteban, Hao Sun, Huating Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0f7e8fe68c21423b8d3fab8d3d749d85
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spelling oai:doaj.org-article:0f7e8fe68c21423b8d3fab8d3d749d852021-12-02T17:33:22ZMyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation10.1038/s41467-019-13598-02041-1723https://doaj.org/article/0f7e8fe68c21423b8d3fab8d3d749d852019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13598-0https://doaj.org/toc/2041-1723Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.Yu ZhaoJiajian ZhouLiangqiang HeYuying LiJie YuanKun SunXiaona ChenXichen BaoMiguel A. EstebanHao SunHuating WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Zhao
Jiajian Zhou
Liangqiang He
Yuying Li
Jie Yuan
Kun Sun
Xiaona Chen
Xichen Bao
Miguel A. Esteban
Hao Sun
Huating Wang
MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
description Enhancers are often transcribed into non-coding RNAs called enhancer RNAs. Here the authors show that super enhancer generated seRNA-1 regulates the expression of nearby myoglobin (Mb) gene by binding to heterogeneous nuclear ribonucleoprotein L during myogenic differentiation.
format article
author Yu Zhao
Jiajian Zhou
Liangqiang He
Yuying Li
Jie Yuan
Kun Sun
Xiaona Chen
Xichen Bao
Miguel A. Esteban
Hao Sun
Huating Wang
author_facet Yu Zhao
Jiajian Zhou
Liangqiang He
Yuying Li
Jie Yuan
Kun Sun
Xiaona Chen
Xichen Bao
Miguel A. Esteban
Hao Sun
Huating Wang
author_sort Yu Zhao
title MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_short MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_full MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_fullStr MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_full_unstemmed MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation
title_sort myod induced enhancer rna interacts with hnrnpl to activate target gene transcription during myogenic differentiation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0f7e8fe68c21423b8d3fab8d3d749d85
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AT jiajianzhou myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT liangqianghe myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT yuyingli myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT jieyuan myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT kunsun myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT xiaonachen myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT xichenbao myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT miguelaesteban myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT haosun myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
AT huatingwang myodinducedenhancerrnainteractswithhnrnpltoactivatetargetgenetranscriptionduringmyogenicdifferentiation
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