Treatment with sodium (S)-2-hydroxyglutarate prevents liver injury in an ischemia-reperfusion model in female Wistar rats

Treatment with sodium (S)-2-hydroxyglutarate prevents liver injury in an ischemia-reperfusion model in female Wistar rats

Background Ischemia-reperfusion (IR) injury is one of the leading causes of early graft dysfunction in liver transplantation. Techniques such as ischemic preconditioning protect the graft through the activation of the hypoxia-inducible factors (HIF), which are downregulated by the EGLN family of pro...

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Autores principales: Eduardo Cienfuegos-Pecina, Diana P. Moreno-Peña, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Diana Garza-Villarreal, Oscar H. Mendoza-Hernández, Raul Alejandro Flores-Cantú, Brenda Alejandra Samaniego Sáenz, Gabriela Alarcon-Galvan, Linda E. Muñoz-Espinosa, Tannya R. Ibarra-Rivera, Alma L. Saucedo, Paula Cordero-Pérez
Formato: article
Lenguaje:EN
Publicado: PeerJ Inc. 2021
Materias:
Ischemia-reperfusion injury
2-hydroxyglutarate
Oxidative stress
Proinflammatory cytokines
Hmox1
Vegfa
Medicine
R
Acceso en línea:https://doaj.org/article/0f9580f0de1b472dae1180650ebbcd4e
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https://doaj.org/article/0f9580f0de1b472dae1180650ebbcd4e

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