Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

14-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across th...

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Bibliographic Details
Main Authors: Gergo Gogl, Kristina V. Tugaeva, Pascal Eberling, Camille Kostmann, Gilles Trave, Nikolai N. Sluchanko
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/1012e611587b4449b559fa63901828a2
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