Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

14-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across th...

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Autores principales:	Gergo Gogl, Kristina V. Tugaeva, Pascal Eberling, Camille Kostmann, Gilles Trave, Nikolai N. Sluchanko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1012e611587b4449b559fa63901828a2
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spelling	oai:doaj.org-article:1012e611587b4449b559fa63901828a22021-12-02T11:39:26ZHierarchized phosphotarget binding by the seven human 14-3-3 isoforms10.1038/s41467-021-21908-82041-1723https://doaj.org/article/1012e611587b4449b559fa63901828a22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21908-8https://doaj.org/toc/2041-172314-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across the proteome.Gergo GoglKristina V. TugaevaPascal EberlingCamille KostmannGilles TraveNikolai N. SluchankoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gergo Gogl Kristina V. Tugaeva Pascal Eberling Camille Kostmann Gilles Trave Nikolai N. Sluchanko Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
description	14-3-3 proteins recognize phosphorylated motifs within numerous protein partners. Here, the authors characterize the binding of all human 14-3-3 isoforms to four E6 oncoproteins, and identify a fixed order of 14-3-3 binding affinities that is conserved in 14-3-3:phosphoprotein interactions across the proteome.
format	article
author	Gergo Gogl Kristina V. Tugaeva Pascal Eberling Camille Kostmann Gilles Trave Nikolai N. Sluchanko
author_facet	Gergo Gogl Kristina V. Tugaeva Pascal Eberling Camille Kostmann Gilles Trave Nikolai N. Sluchanko
author_sort	Gergo Gogl
title	Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
title_short	Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
title_full	Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
title_fullStr	Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
title_full_unstemmed	Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
title_sort	hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1012e611587b4449b559fa63901828a2
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Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms

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