Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.

Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex possessing two essential sub-units, Sec61p/Sec61α and Sss1p/Sec61γ and the non-essential Sbh1p/Sec61β subunit. In addition to forming a protein cond...

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Autores principales: Christopher M Witham, Aleshanee L Paxman, Lamprini Baklous, Robert F L Steuart, Benjamin L Schulz, Carl J Mousley
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/1017cb428036497fb1393b41215a322f
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