Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.

Translocation of secretory and integral membrane proteins across or into the ER membrane occurs via the Sec61 complex, a heterotrimeric protein complex possessing two essential sub-units, Sec61p/Sec61α and Sss1p/Sec61γ and the non-essential Sbh1p/Sec61β subunit. In addition to forming a protein cond...

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Detalles Bibliográficos
Autores principales: Christopher M Witham, Aleshanee L Paxman, Lamprini Baklous, Robert F L Steuart, Benjamin L Schulz, Carl J Mousley
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/1017cb428036497fb1393b41215a322f
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