Direct amidation of esters with nitroarenes

Direct amidation of esters with nitroarenes

Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.

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Autores principales: Chi Wai Cheung, Marten Leendert Ploeger, Xile Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/10b081dbcf634db29252db615d5ffd3a
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spelling oai:doaj.org-article:10b081dbcf634db29252db615d5ffd3a2021-12-02T14:40:49ZDirect amidation of esters with nitroarenes10.1038/ncomms148782041-1723https://doaj.org/article/10b081dbcf634db29252db615d5ffd3a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14878https://doaj.org/toc/2041-1723Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.Chi Wai CheungMarten Leendert PloegerXile HuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chi Wai Cheung
Marten Leendert Ploeger
Xile Hu
Direct amidation of esters with nitroarenes
description Direct conversion of esters to amides, while attractive, is often limited to activated esters or highly nucleophilic amines. Here the authors report a nickel-catalysed reductive coupling between unactivated esters and nitroarenes, giving a direct route to aromatic amides.
format article
author Chi Wai Cheung
Marten Leendert Ploeger
Xile Hu
author_facet Chi Wai Cheung
Marten Leendert Ploeger
Xile Hu
author_sort Chi Wai Cheung
title Direct amidation of esters with nitroarenes
title_short Direct amidation of esters with nitroarenes
title_full Direct amidation of esters with nitroarenes
title_fullStr Direct amidation of esters with nitroarenes
title_full_unstemmed Direct amidation of esters with nitroarenes
title_sort direct amidation of esters with nitroarenes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/10b081dbcf634db29252db615d5ffd3a
work_keys_str_mv AT chiwaicheung directamidationofesterswithnitroarenes
AT martenleendertploeger directamidationofesterswithnitroarenes
AT xilehu directamidationofesterswithnitroarenes
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