Improvement of antibody functionality by structure-guided paratope engraftment

Quaternary contacts mediated by an extended heavy-chain framework region 3 (FR3) have been shown to improve binding to HIV envelope and virus neutralization for a few antibodies. Here, Liu et al. engraft such an FR3 loop onto several potent broadly neutralizing antibodies, resulting in improved neut...

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Autores principales:	Qingbo Liu, Yen-Ting Lai, Peng Zhang, Mark K. Louder, Amarendra Pegu, Reda Rawi, Mangaiarkarasi Asokan, Xuejun Chen, Chen-Hsiang Shen, Gwo-Yu Chuang, Eun Sung Yang, Huiyi Miao, Yuge Wang, Anthony S. Fauci, Peter D. Kwong, John R. Mascola, Paolo Lusso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10b7f1c587ee4bb1b5830cf566829a7e
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spelling	oai:doaj.org-article:10b7f1c587ee4bb1b5830cf566829a7e2021-12-02T16:58:15ZImprovement of antibody functionality by structure-guided paratope engraftment10.1038/s41467-019-08658-42041-1723https://doaj.org/article/10b7f1c587ee4bb1b5830cf566829a7e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08658-4https://doaj.org/toc/2041-1723Quaternary contacts mediated by an extended heavy-chain framework region 3 (FR3) have been shown to improve binding to HIV envelope and virus neutralization for a few antibodies. Here, Liu et al. engraft such an FR3 loop onto several potent broadly neutralizing antibodies, resulting in improved neutralization activity and pharmacokinetics.Qingbo LiuYen-Ting LaiPeng ZhangMark K. LouderAmarendra PeguReda RawiMangaiarkarasi AsokanXuejun ChenChen-Hsiang ShenGwo-Yu ChuangEun Sung YangHuiyi MiaoYuge WangAnthony S. FauciPeter D. KwongJohn R. MascolaPaolo LussoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingbo Liu Yen-Ting Lai Peng Zhang Mark K. Louder Amarendra Pegu Reda Rawi Mangaiarkarasi Asokan Xuejun Chen Chen-Hsiang Shen Gwo-Yu Chuang Eun Sung Yang Huiyi Miao Yuge Wang Anthony S. Fauci Peter D. Kwong John R. Mascola Paolo Lusso Improvement of antibody functionality by structure-guided paratope engraftment
description	Quaternary contacts mediated by an extended heavy-chain framework region 3 (FR3) have been shown to improve binding to HIV envelope and virus neutralization for a few antibodies. Here, Liu et al. engraft such an FR3 loop onto several potent broadly neutralizing antibodies, resulting in improved neutralization activity and pharmacokinetics.
format	article
author	Qingbo Liu Yen-Ting Lai Peng Zhang Mark K. Louder Amarendra Pegu Reda Rawi Mangaiarkarasi Asokan Xuejun Chen Chen-Hsiang Shen Gwo-Yu Chuang Eun Sung Yang Huiyi Miao Yuge Wang Anthony S. Fauci Peter D. Kwong John R. Mascola Paolo Lusso
author_facet	Qingbo Liu Yen-Ting Lai Peng Zhang Mark K. Louder Amarendra Pegu Reda Rawi Mangaiarkarasi Asokan Xuejun Chen Chen-Hsiang Shen Gwo-Yu Chuang Eun Sung Yang Huiyi Miao Yuge Wang Anthony S. Fauci Peter D. Kwong John R. Mascola Paolo Lusso
author_sort	Qingbo Liu
title	Improvement of antibody functionality by structure-guided paratope engraftment
title_short	Improvement of antibody functionality by structure-guided paratope engraftment
title_full	Improvement of antibody functionality by structure-guided paratope engraftment
title_fullStr	Improvement of antibody functionality by structure-guided paratope engraftment
title_full_unstemmed	Improvement of antibody functionality by structure-guided paratope engraftment
title_sort	improvement of antibody functionality by structure-guided paratope engraftment
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/10b7f1c587ee4bb1b5830cf566829a7e
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Improvement of antibody functionality by structure-guided paratope engraftment

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