Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in <named-content content-type="genus-species">Escherichia coli</named-content>

Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in <named-content content-type="genus-species">Escherichia coli</named-content>

ABSTRACT Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an economically important flavor compound that can be made in bacterial cell factories, but toxicity is a major problem for cells producing this aromatic aldehyde. Using (i) a global proteomic analysis supported by multiple physiological experim...

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Bibliographic Details
Main Authors: Calum A. Pattrick, Joseph P. Webb, Jeffrey Green, Roy R. Chaudhuri, Mark O. Collins, David J. Kelly
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
aldehyde
adaptive evolution
citrate synthase
copper
proteomics
stress responses
Microbiology
QR1-502
Online Access:https://doaj.org/article/10c3d95be6f54fd59c67de743b7d24dd
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