Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides
Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. <i>Erythrina edulis</i> (pajuro) is a legume with a large number of high-qualit...
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2021
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oai:doaj.org-article:10cd4d0807be434bb1dd8aacfde6f9382021-11-25T16:27:13ZAlbumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides10.3390/antiox101117222076-3921https://doaj.org/article/10cd4d0807be434bb1dd8aacfde6f9382021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1722https://doaj.org/toc/2076-3921Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. <i>Erythrina edulis</i> (pajuro) is a legume with a large number of high-quality proteins, of which their potential as a source of antioxidant peptides has been recently reported. In this study, the behavior of these proteins under a sequential enzymatic hydrolysis with digestive and microbial enzymes was investigated by evaluating the multi-functionality of the hydrolyzates. The albumin hydrolyzates obtained after the action of pepsin, pancreatin, and Alcalase showed antioxidant, angiotensin-converting enzyme (ACE), α-amylase, α-glucosidase, and dipeptidyl peptidase (DPP)-IV inhibitory activities. The radical scavenging properties of the hydrolyzate could be responsible for the potent protective effects observed in FeSO<sub>4</sub>-induced neuroblastoma cells. The findings support the role of pajuro protein as an ingredient of functional foods or nutraceuticals for health promotion and the prevention of oxidative stress, hypertension, and metabolic alteration-associated chronic diseases.Cleni Palma-AlbinoArturo IntiquillaKarim Jiménez-AliagaNathaly Rodríguez-AranaEstela SolanoEduardo FloresAmparo Iris ZavaletaVíctor IzaguirreBlanca Hernández-LedesmaMDPI AGarticle<i>Erythrina edulis</i>legume proteinssequential enzymatic digestionmultifunctional peptidesTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1722, p 1722 (2021) |
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<i>Erythrina edulis</i> legume proteins sequential enzymatic digestion multifunctional peptides Therapeutics. Pharmacology RM1-950 |
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<i>Erythrina edulis</i> legume proteins sequential enzymatic digestion multifunctional peptides Therapeutics. Pharmacology RM1-950 Cleni Palma-Albino Arturo Intiquilla Karim Jiménez-Aliaga Nathaly Rodríguez-Arana Estela Solano Eduardo Flores Amparo Iris Zavaleta Víctor Izaguirre Blanca Hernández-Ledesma Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
description |
Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. <i>Erythrina edulis</i> (pajuro) is a legume with a large number of high-quality proteins, of which their potential as a source of antioxidant peptides has been recently reported. In this study, the behavior of these proteins under a sequential enzymatic hydrolysis with digestive and microbial enzymes was investigated by evaluating the multi-functionality of the hydrolyzates. The albumin hydrolyzates obtained after the action of pepsin, pancreatin, and Alcalase showed antioxidant, angiotensin-converting enzyme (ACE), α-amylase, α-glucosidase, and dipeptidyl peptidase (DPP)-IV inhibitory activities. The radical scavenging properties of the hydrolyzate could be responsible for the potent protective effects observed in FeSO<sub>4</sub>-induced neuroblastoma cells. The findings support the role of pajuro protein as an ingredient of functional foods or nutraceuticals for health promotion and the prevention of oxidative stress, hypertension, and metabolic alteration-associated chronic diseases. |
format |
article |
author |
Cleni Palma-Albino Arturo Intiquilla Karim Jiménez-Aliaga Nathaly Rodríguez-Arana Estela Solano Eduardo Flores Amparo Iris Zavaleta Víctor Izaguirre Blanca Hernández-Ledesma |
author_facet |
Cleni Palma-Albino Arturo Intiquilla Karim Jiménez-Aliaga Nathaly Rodríguez-Arana Estela Solano Eduardo Flores Amparo Iris Zavaleta Víctor Izaguirre Blanca Hernández-Ledesma |
author_sort |
Cleni Palma-Albino |
title |
Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
title_short |
Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
title_full |
Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
title_fullStr |
Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
title_full_unstemmed |
Albumin from <i>Erythrina edulis</i> (Pajuro) as a Promising Source of Multifunctional Peptides |
title_sort |
albumin from <i>erythrina edulis</i> (pajuro) as a promising source of multifunctional peptides |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/10cd4d0807be434bb1dd8aacfde6f938 |
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