A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

Beta II protein kinase C (βIIPKC) activation contributes to heart failure. Here the authors show, in a rat model of myocardial infarction, that heart failure outcome can be improved by selectively inhibiting the interaction between βIIPKC and its downstream mitochondrial target Mitofusin-1, and that...

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Autores principales: Julio C. B. Ferreira, Juliane C. Campos, Nir Qvit, Xin Qi, Luiz H. M. Bozi, Luiz R. G. Bechara, Vanessa M. Lima, Bruno B. Queliconi, Marie-Helene Disatnik, Paulo M. M. Dourado, Alicia J. Kowaltowski, Daria Mochly-Rosen
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/10da15e390414801950d6b6ca5915d4c
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spelling oai:doaj.org-article:10da15e390414801950d6b6ca5915d4c2021-12-02T15:35:09ZA selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats10.1038/s41467-018-08276-62041-1723https://doaj.org/article/10da15e390414801950d6b6ca5915d4c2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08276-6https://doaj.org/toc/2041-1723Beta II protein kinase C (βIIPKC) activation contributes to heart failure. Here the authors show, in a rat model of myocardial infarction, that heart failure outcome can be improved by selectively inhibiting the interaction between βIIPKC and its downstream mitochondrial target Mitofusin-1, and that this strategy is superior to global βIIPKC inhibition.Julio C. B. FerreiraJuliane C. CamposNir QvitXin QiLuiz H. M. BoziLuiz R. G. BecharaVanessa M. LimaBruno B. QueliconiMarie-Helene DisatnikPaulo M. M. DouradoAlicia J. KowaltowskiDaria Mochly-RosenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julio C. B. Ferreira
Juliane C. Campos
Nir Qvit
Xin Qi
Luiz H. M. Bozi
Luiz R. G. Bechara
Vanessa M. Lima
Bruno B. Queliconi
Marie-Helene Disatnik
Paulo M. M. Dourado
Alicia J. Kowaltowski
Daria Mochly-Rosen
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
description Beta II protein kinase C (βIIPKC) activation contributes to heart failure. Here the authors show, in a rat model of myocardial infarction, that heart failure outcome can be improved by selectively inhibiting the interaction between βIIPKC and its downstream mitochondrial target Mitofusin-1, and that this strategy is superior to global βIIPKC inhibition.
format article
author Julio C. B. Ferreira
Juliane C. Campos
Nir Qvit
Xin Qi
Luiz H. M. Bozi
Luiz R. G. Bechara
Vanessa M. Lima
Bruno B. Queliconi
Marie-Helene Disatnik
Paulo M. M. Dourado
Alicia J. Kowaltowski
Daria Mochly-Rosen
author_facet Julio C. B. Ferreira
Juliane C. Campos
Nir Qvit
Xin Qi
Luiz H. M. Bozi
Luiz R. G. Bechara
Vanessa M. Lima
Bruno B. Queliconi
Marie-Helene Disatnik
Paulo M. M. Dourado
Alicia J. Kowaltowski
Daria Mochly-Rosen
author_sort Julio C. B. Ferreira
title A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
title_short A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
title_full A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
title_fullStr A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
title_full_unstemmed A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats
title_sort selective inhibitor of mitofusin 1-βiipkc association improves heart failure outcome in rats
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/10da15e390414801950d6b6ca5915d4c
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