Curvotaxis directs cell migration through cell-scale curvature landscapes

The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis.

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Autores principales:	Laurent Pieuchot, Julie Marteau, Alain Guignandon, Thomas Dos Santos, Isabelle Brigaud, Pierre-François Chauvy, Thomas Cloatre, Arnaud Ponche, Tatiana Petithory, Pablo Rougerie, Maxime Vassaux, Jean-Louis Milan, Nayana Tusamda Wakhloo, Arnaud Spangenberg, Maxence Bigerelle, Karine Anselme
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/110d3deece5b4a78ab42eb5f8f125038
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spelling	oai:doaj.org-article:110d3deece5b4a78ab42eb5f8f1250382021-12-02T15:33:58ZCurvotaxis directs cell migration through cell-scale curvature landscapes10.1038/s41467-018-06494-62041-1723https://doaj.org/article/110d3deece5b4a78ab42eb5f8f1250382018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06494-6https://doaj.org/toc/2041-1723The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis.Laurent PieuchotJulie MarteauAlain GuignandonThomas Dos SantosIsabelle BrigaudPierre-François ChauvyThomas CloatreArnaud PoncheTatiana PetithoryPablo RougerieMaxime VassauxJean-Louis MilanNayana Tusamda WakhlooArnaud SpangenbergMaxence BigerelleKarine AnselmeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laurent Pieuchot Julie Marteau Alain Guignandon Thomas Dos Santos Isabelle Brigaud Pierre-François Chauvy Thomas Cloatre Arnaud Ponche Tatiana Petithory Pablo Rougerie Maxime Vassaux Jean-Louis Milan Nayana Tusamda Wakhloo Arnaud Spangenberg Maxence Bigerelle Karine Anselme Curvotaxis directs cell migration through cell-scale curvature landscapes
description	The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis.
format	article
author	Laurent Pieuchot Julie Marteau Alain Guignandon Thomas Dos Santos Isabelle Brigaud Pierre-François Chauvy Thomas Cloatre Arnaud Ponche Tatiana Petithory Pablo Rougerie Maxime Vassaux Jean-Louis Milan Nayana Tusamda Wakhloo Arnaud Spangenberg Maxence Bigerelle Karine Anselme
author_facet	Laurent Pieuchot Julie Marteau Alain Guignandon Thomas Dos Santos Isabelle Brigaud Pierre-François Chauvy Thomas Cloatre Arnaud Ponche Tatiana Petithory Pablo Rougerie Maxime Vassaux Jean-Louis Milan Nayana Tusamda Wakhloo Arnaud Spangenberg Maxence Bigerelle Karine Anselme
author_sort	Laurent Pieuchot
title	Curvotaxis directs cell migration through cell-scale curvature landscapes
title_short	Curvotaxis directs cell migration through cell-scale curvature landscapes
title_full	Curvotaxis directs cell migration through cell-scale curvature landscapes
title_fullStr	Curvotaxis directs cell migration through cell-scale curvature landscapes
title_full_unstemmed	Curvotaxis directs cell migration through cell-scale curvature landscapes
title_sort	curvotaxis directs cell migration through cell-scale curvature landscapes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/110d3deece5b4a78ab42eb5f8f125038
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Curvotaxis directs cell migration through cell-scale curvature landscapes

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