BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.

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Detalles Bibliográficos
Autores principales: Jekaterina Vohhodina, Liana J. Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev Jr., Mai Huynh, Zhiqi Liu, Fieda O. Abderazzaq, Allison P. Clark, Scott B. Ficarro, Jarrod A. Marto, Elodie Hatchi, David M. Livingston
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107
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https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107

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