BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage

BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.

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Autores principales: Jekaterina Vohhodina, Liana J. Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev Jr., Mai Huynh, Zhiqi Liu, Fieda O. Abderazzaq, Allison P. Clark, Scott B. Ficarro, Jarrod A. Marto, Elodie Hatchi, David M. Livingston
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107
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spelling oai:doaj.org-article:111700d569e04bcc80c6ff1a6421e1072021-12-02T14:58:18ZBRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage10.1038/s41467-021-23716-62041-1723https://doaj.org/article/111700d569e04bcc80c6ff1a6421e1072021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23716-6https://doaj.org/toc/2041-1723BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.Jekaterina VohhodinaLiana J. GoehringBen LiuQing KongVladimir V. Botchkarev Jr.Mai HuynhZhiqi LiuFieda O. AbderazzaqAllison P. ClarkScott B. FicarroJarrod A. MartoElodie HatchiDavid M. LivingstonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jekaterina Vohhodina
Liana J. Goehring
Ben Liu
Qing Kong
Vladimir V. Botchkarev Jr.
Mai Huynh
Zhiqi Liu
Fieda O. Abderazzaq
Allison P. Clark
Scott B. Ficarro
Jarrod A. Marto
Elodie Hatchi
David M. Livingston
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
description BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.
format article
author Jekaterina Vohhodina
Liana J. Goehring
Ben Liu
Qing Kong
Vladimir V. Botchkarev Jr.
Mai Huynh
Zhiqi Liu
Fieda O. Abderazzaq
Allison P. Clark
Scott B. Ficarro
Jarrod A. Marto
Elodie Hatchi
David M. Livingston
author_facet Jekaterina Vohhodina
Liana J. Goehring
Ben Liu
Qing Kong
Vladimir V. Botchkarev Jr.
Mai Huynh
Zhiqi Liu
Fieda O. Abderazzaq
Allison P. Clark
Scott B. Ficarro
Jarrod A. Marto
Elodie Hatchi
David M. Livingston
author_sort Jekaterina Vohhodina
title BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
title_short BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
title_full BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
title_fullStr BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
title_full_unstemmed BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage
title_sort brca1 binds terra rna and suppresses r-loop-based telomeric dna damage
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107
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