Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an allosteric effector of the enzyme.

Saved in:
Bibliographic Details
Main Authors: Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos, Albert M. Berghuis
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Q
Online Access:https://doaj.org/article/111b9b63900a4b0cbd2922f6e1276728
Tags: Add Tag
No Tags, Be the first to tag this record!