Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an allosteric effector of the enzyme.

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Autores principales:	Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos, Albert M. Berghuis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/111b9b63900a4b0cbd2922f6e1276728
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spelling	oai:doaj.org-article:111b9b63900a4b0cbd2922f6e12767282021-12-02T14:42:40ZHuman farnesyl pyrophosphate synthase is allosterically inhibited by its own product10.1038/ncomms141322041-1723https://doaj.org/article/111b9b63900a4b0cbd2922f6e12767282017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14132https://doaj.org/toc/2041-1723Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an allosteric effector of the enzyme.Jaeok ParkMichal ZielinskiAlexandr MagderYoula S. TsantrizosAlbert M. BerghuisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jaeok Park Michal Zielinski Alexandr Magder Youla S. Tsantrizos Albert M. Berghuis Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
description	Farnesyl pyrophosphate (FPP) is a key building block for the synthesis of many lipids. Here the authors determine the crystal structure of farnesyl pyrophosphate synthase (FPPS) with its bound product and use kinetic measurements to show that FPP is an allosteric effector of the enzyme.
format	article
author	Jaeok Park Michal Zielinski Alexandr Magder Youla S. Tsantrizos Albert M. Berghuis
author_facet	Jaeok Park Michal Zielinski Alexandr Magder Youla S. Tsantrizos Albert M. Berghuis
author_sort	Jaeok Park
title	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
title_short	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
title_full	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
title_fullStr	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
title_full_unstemmed	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
title_sort	human farnesyl pyrophosphate synthase is allosterically inhibited by its own product
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/111b9b63900a4b0cbd2922f6e1276728
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Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

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