Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis
Abstract Background Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns. The frequency of potentially oncogenic integrations has been reported in o...
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Auteurs principaux: | Alejandro A. Schäffer, Dana A. Dominguez, Lesley M. Chapman, E. Michael Gertz, Anuradha Budhu, Marshonna Forgues, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Xiaolin Wu, Enkhjargal Bayarsaikhan, Curtis C. Harris, Mathuros Ruchirawat, Eytan Ruppin, Xin Wei Wang |
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Format: | article |
Langue: | EN |
Publié: |
BMC
2021
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Sujets: | |
Accès en ligne: | https://doaj.org/article/112941e99568473c8c4542fa2d87f042 |
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