Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.

Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.

<h4>Background</h4>A homeostatic relationship with the intestinal microflora is increasingly appreciated as essential for human health and wellbeing. Mutations in the leucine-rich repeat (LRR) domain of Nod2, a bacterial recognition protein, are associated with development of the inflamm...

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Bibliographic Details
Main Authors: Laurent-Herve Perez, Matt Butler, Tammy Creasey, JoAnn Dzink-Fox, John Gounarides, Stephanie Petit, Anna Ropenga, Neil Ryder, Kathryn Smith, Philip Smith, Scott J Parkinson
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/1133fe159fb844d2877b522597347e56
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https://doaj.org/article/1133fe159fb844d2877b522597347e56

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