Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's disease-associated mutations.
<h4>Background</h4>A homeostatic relationship with the intestinal microflora is increasingly appreciated as essential for human health and wellbeing. Mutations in the leucine-rich repeat (LRR) domain of Nod2, a bacterial recognition protein, are associated with development of the inflamm...
Guardado en:
Autores principales: | Laurent-Herve Perez, Matt Butler, Tammy Creasey, JoAnn Dzink-Fox, John Gounarides, Stephanie Petit, Anna Ropenga, Neil Ryder, Kathryn Smith, Philip Smith, Scott J Parkinson |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1133fe159fb844d2877b522597347e56 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
por: Nicolas Rochereau, et al.
Publicado: (2021) -
Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease
por: Julie E. Horowitz, et al.
Publicado: (2021) -
Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
por: Yun Chen, et al.
Publicado: (2017) -
NOD/scid IL‐2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype
por: Anna‐Lena Unterweger, et al.
Publicado: (2021) -
The Transnistrian Compromise?
por: I. S. PUTINTSEV
Publicado: (2010)